Ct = 0.92e -0.35t
where Ct is in units of mg/L and the time (t) is in hours.
If the dose is 50mg calculate the following:
|Plasma Concentration (mg/L)||2.6||2.4||2.1||1.2||0.75||0.45||0.2|
Calculate the volume of distribution, plasma half-life and clearance of X.
X was subsequently administered via the oral route at a dose of 200mg as both an aqueous solution and as a formulated product. The measured areas under the plasma concentration time curves were 14.3 mg/L.h and 12.6 mg/L.h for the solution dose and formulated product respectively.
Using this data calculate the relative and absolute bioavailability of X.
Using the above data:
|Plasma Concentration (mg/L)||0.33||1.0||1.8||2.02||2.0||1.6||1.0||0.6||0.38|
Calculate the absorption and elimination rate constants, the volume of distribution and clearance of Y assuming that F, the bioavailability, is equal to 0.75.
If the 100mg oral dose is repeated at 8 hourly intervals calculate the maximum, minimum and average steady-state plasma concentrations.
At 4.00pm on day 2 a plasma sample was analysed for A and a concentration of 6mg/L was obtained.
Is this measured concentration consistent with the expected value?
Volume of distribution of A is 14.5L and clearance is 40mL/min.
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